Turbo won’t run out of the blue!

Have a 14 1000, turboed with a PC-5 and an Autotune. It’s been running awesome then out of the blue it’s running terrible. Sometimes I can get it run ok at 10lbs of boost but anymore and it appears to go lean. Sometimes it goes full lean, off the charts and won’t run at all. the Next time it will pop and fart and the A/F will bounce around from 12 to 16.
I’ve changed the Autotune O2 sensor, checked all wire plugs, fuel pressure holds steady at 55lbs, tried to run without Autotune. Changed plugs etc. Could the PC-5 have just quit compensating? I’m assuming it’s just not getting fuel but don’t know where to start. Have to get this running, thanks in advance for any help. Dan